Loot them now. Take it all.

Posted: 17th January 2022 by Khannea Suntzu in Uncategorized

What Are the Solutions to the Climate Crisis?

Posted: 17th January 2022 by Khannea Suntzu in Uncategorized

We’re using our streets all wrong

Posted: 16th January 2022 by Khannea Suntzu in Uncategorized

Targeting the biological causes of ageing could be one method for better treating multimorbidity. 

Over half of UK adults over the age of 65 live with two or more long-term health conditions—commonly known as multimorbidity. People living with multimorbidity not only have a shorter life expectancy, but they may also experience poorer physical and mental health.

Crucially, over half of GP consultations and hospital appointments involve patients with multimorbidity. In the UK, care for people with multimorbidity is also estimated to take up to 70% of health and social care expenditure. With an aging population, it’s expected that the number of people living with multimorbidity will rise. This could place an even greater demand on the NHS by patients needing long term treatment.

Multimorbidity is currently managed by treating each disease separately. This means people will need to take multiple medications at the same time (known as polypharmacy), and will also have to attend multiple medical appointments for each condition. Not only can this put a strain on the NHS, polypharmacy can also put patients at increased risk of negative drug interactions and unintended harm.

There’s a clear need to improve the way multimorbidity is treated. But research shows that to do this, we need to instead start looking at targeting the key causes of multimorbidity when searching for treatments.

A new approach

Although multimorbidity differs for each person, we know that patients tend to suffer from the same groups of diseases—known as “clusters“. This suggests that each cluster may share a common underlying cause. For example, a person with multimorbidity may suffer from heart problems (such as heart disease and high blood pressure) and diabetes, which may all stem from the same cause—such as obesity.

Identifying and treating the cause of a patient’s disease clusters would allow us to more effectively combat several—or even all—of the diseases a patient has using a single treatment. This would both reduce the number of medical appointments a person needs to attend and the number of medications they may need to take.

Such an approach has not yet been taken, in large part because  and  tends to focus on treating a single disease, instead of multiple. So any breakthroughs in this field could be many years off unless action is taken now.

Importantly one of the biggest risk factors for developing multimorbidity is getting older. This is why researchers think targeting the biological causes of aging could be one way of treating multimorbidity, by preventing clusters of diseases from developing in the first place.

Aging is characterized by nine changes—known as the “hallmarks of aging“—that occur in our  and molecules. These changes result from a build-up of damage in the body, which then stresses our cells and causes them to enter a state known as cell senescence, where the cell stops dividing and then causes further damage to healthy cells.

We become less able to remove  from our body as we get older, causing them to accumulate and increase our risk of disease. Researchers think that if we could prevent these cells from building up, we may be better able to prevent multimorbidity from happening to begin with.

Research on mice that were genetically engineered to have no senescent cells showed they lived 25% longer and had less multimorbidity than normal mice. But mice that had been genetically engineered to have increased cell senescence aged faster and developed multimorbidity younger. Though the same will need to be proven in humans, these early results show targeting senescent cells may have promise in preventing multimorbidity.

Drugs which can kill senescent cells (called senolytics) already exist, and are currently used to treat certain types of leukemia, and are now being trialed on patients with the chronic lung condition idiopathic pulmonary fibrosis. Given senolytics are already in , this means they could quickly be repurposed for use in patients with multimorbidity if proven to be effective on other conditions too.

Physical activity may also be another way to target senescent cells. Studies on mice have shown that exercise can help reduce the number of senescent cells in the body. Some evidence also indicates the same is true for humans. One study, which had  follow a daily exercise program for 12 weeks, found that not only did participants’ physical function improve, the number of senescent cells they had in their blood was reduced.

But before we can use this kind of approach in treating multimorbidity, more research will be needed. Not only do we need to show that drugs which target biological aging work at preventing and treating multimorbidity in humans, we also need to identify which hallmarks of aging are driving clusters of  to develop in patients with multimorbidity.

With an aging population in many countries around the world, multimorbidity is likely to only become more common unless a radical new approach is taken to tackle it. Better treatments alone could have a major impact on improving the physical and mental health of patients worldwide—while also alleviating pressure on healthcare systems.

Source: MedicalExpress

I support ANTIFA

Posted: 15th January 2022 by Khannea Suntzu in Uncategorized

Darwin 4 – Expedition

Posted: 14th January 2022 by Khannea Suntzu in Uncategorized

Where are they now?

Posted: 11th January 2022 by Khannea Suntzu in Uncategorized

The managerial class is doomed

Posted: 11th January 2022 by Khannea Suntzu in Uncategorized

Birds are a communist hoax

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

22 Innovations Arriving 2022

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

How Technology might be about to Kill us.

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

Basically Republican Evangelicals

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

What If We Created a Superintelligence?

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

This generation can end the United States

Posted: 9th January 2022 by Khannea Suntzu in Uncategorized

Look at the immense eviul the United States has wrought upon the people of the wotld, upon the economies and wellbeing of the world, to the ecologies of the planet, to the future of humanity. Genocide after genocide, generations of pentagon driven economic hitmen, arms exports and torture experts active in right wing dictatorships in every continent except antarctica. In the US next to nobody will acknowledge it – outside the UD everyone can see it plainly. The United States has become truly evil.  Half its population is pervasively white supremacist and racist, soiopathically corporatist, insane evangelical, is innundated with murderous weapons, completely in denial about basic scientific fact, actively desiring the contribute to climate disasters, ruthlessly unilateralist and using its power to make it worse.

Yet never before has the United States been as divided and fragile. Even a most minimalist shove from the outside can lay waste to the credibility of the US for generations. Just a superficial spin of conspiracy theories, and the country is coming apart at the seams. Throw a global pandemic on the country and they criminally accept millions die under horrific conditions, and they deny it even exists. Where the Roman empire, with all its sadism, started rotting from the inside it took many decades for the empire to end. Everythig happens much faster these days, and where we knew the US was completely insolvent in any metric as a world empire just a decade ago, now we know this house of cards can not hope to stand, especially not in this rainstorm. The US is ending before out eyes.

We need to expedite this process and utterly seek to wreck this evil hot mess as soon as possible. The end of this monstropus apparatus will actually reduce the suffering of its populace – the sooner the US is facilitated in ripping itself apart, the quicker the civilized world can stat reinvesting in rational democratic, social-democratic institutions and governmental infrastructure and insert this humane nation building back into the US. The collapse of the US itself will be quick and merciful. The world must  take steps to keep the insanity locked inside the US and close borders for the rats fleeing this sinking ship. We already know that most the US corporations, billionaires and even government officials have long since established survivalist bolt-holes all ovet the planet. This is tragic, as this will introduce the US psychosis all over the planet, but we may yet be able to cauterize this affliction after the fact. We may be able to throw out the likes of jeff bezos off New Zealand, and Trump from schotland. Other examples abound. 

The end of the US is manageable, with all it’s nuclear weapons, wil all it’s state power and military colonies worldwide. We must escort all these imperial bases and their staff politely back to the counttry as quickly as possible.

That’s why I  call for the creatiun of The Institute For The End Of The United States, literally. This institute should be founded in Amsterdam and will be an activist think tank dead set on curtailing the most evil aspects of the Unite States, to facilitate a peaceful end to the United States, to contain US influence outside the US, in particular right wing influence. And most of all, this institute will aide in rebuilding the US to become a series of seceded states, each either enthusiastically social-democrat, just. civilized, putting its citizens first, the climate first, judicial oversight first. I personally don’t see a future for a US that remains one single political unity. I prefer at least several new countries emerge in the wake of the US, much as the dissolution of the Soviet Union. 

I may be remarkably easy to enter this transition, and chip away at a fragile and allready collapsing United States. There are enbdless opportunities to crowbar it wide apart, all with completely legal means from the EU. We don’t need to stoop to the level  of CIA blackops human rights violatuions – just revealing the facts will be sufficient to bring down this other evil empire. 

If you like this, reach out. You know how to contact me. I need sponsors and friends to make this Institute a reality. You know my unswerving dedication. I’d like to get going as quickly as possible, for the future of humanity. 

We can do this.

Warts and all

Posted: 8th January 2022 by Khannea Suntzu in Uncategorized

Should we have maximum incomes?

Posted: 8th January 2022 by Khannea Suntzu in Uncategorized

SHOULD THERE BE A MAXIMUM WAGE?

 

The corn demands your blood

Posted: 8th January 2022 by Khannea Suntzu in Uncategorized

Why is Ukraine the West’s Fault?

Posted: 8th January 2022 by Khannea Suntzu in Uncategorized

When presidents still cared

Posted: 8th January 2022 by Khannea Suntzu in Uncategorized

Why Is American Fascism On The Rise?

Posted: 6th January 2022 by Khannea Suntzu in Uncategorized
Comments Off on Why Is American Fascism On The Rise?

The Methamphetamine Epidemic

Posted: 6th January 2022 by Khannea Suntzu in Uncategorized
Comments Off on The Methamphetamine Epidemic

What the fuck is wrong with you americans??

Posted: 5th January 2022 by Khannea Suntzu in Uncategorized
Comments Off on What the fuck is wrong with you americans??

Revealed: majority of people charged in Capitol attack aren’t in jail

Monsters. The real monsters.

Posted: 4th January 2022 by Khannea Suntzu in Uncategorized
Comments Off on Monsters. The real monsters.